CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02460
Pert ID:	BRD-K16664969
Compound Name:	GTP-14564
Targets:	CSF1R\|FLT3\|KIT\|PDGFRB
MoA:	FLT3 inhibitor; tyrosine kinase inhibitor
SMILES:	c1ccc(cc1)-c1n[nH]c2c1oc1ccccc21
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2843	BRD-K16664969	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3337	BRD-K16664969	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
3733	BRD-K16664969	VCAP	10 uM	24 h	-0.27	-1.13	0.4	0.0	0.0	0.0
39303	BRD-K16664969	A549	10 uM	24 h	-0.26	-1.06	0.26	-0.26	-0.88	0.26
39636	BRD-K16664969	ASC	10 uM	24 h	-0.21	-0.89	0.04	0.0	0.0	0.0
39952	BRD-K16664969	HEPG2	10 uM	6 h	-0.32	-1.33	0.91	-0.31	-1.06	0.73
40233	BRD-K16664969	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40455	BRD-K16664969	MCF??7.00	10 uM	24 h	0.2	0.84	0.0	-0.33	-1.1	0.86
41060	BRD-K16664969	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41389	BRD-K16664969	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97167	BRD-K16664969	A375	10 uM	24 h	0.27	1.13	0.28	0.22	0.77	0.06
97232	BRD-K16664969	PC3	10 uM	24 h	-0.2	-0.85	0.01	0.25	0.87	0.17
100152	BRD-K16664969	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary