Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C02468
Pert ID: BRD-K32830106
Compound Name: guanfacine
Targets: ADRA2A|ADRA2B|ADRA2C
MoA: adrenergic receptor agonist
SMILES: NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5316 BRD-K32830106 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5767 BRD-K32830106 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5901 BRD-K32830106 HEPG2 10 uM 6 h -0.23 -0.97 0.11 -0.25 -0.85 0.19
6015 BRD-K32830106 HT29 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.2
6270 BRD-K32830106 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6537 BRD-K32830106 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37142 BRD-K32830106 A375 10 uM 6 h 0.2 0.84 0.0 -0.27 -0.9 0.28
37377 BRD-K32830106 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37635 BRD-K32830106 ASC 10 uM 24 h -0.25 -1.05 0.24 0.24 0.85 0.15
38196 BRD-K32830106 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38461 BRD-K32830106 NPC 10 uM 24 h -0.23 -0.97 0.11 -0.52 -1.77 15.65
38941 BRD-K32830106 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
99849 BRD-K32830106 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).