CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02502
Pert ID:	BRD-K27737647
Compound Name:	H-89
Targets:	GSG2\|PKIA\|PRKACA
MoA:	PKA inhibitor
SMILES:	Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1573	BRD-K27737647	HA1E	10 uM	24 h	0.24	0.98	0.09	0.0	0.0	0.0
1908	BRD-K27737647	HCC515	10 uM	24 h	0.0	0.0	0.0	0.4	1.4	2.18
2163	BRD-K27737647	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
2647	BRD-K27737647	VCAP	10 uM	6 h	0.0	0.0	0.0	0.34	1.19	1.02
41925	BRD-K27737647	A549	10 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.25
42340	BRD-K27737647	ASC	10 uM	24 h	0.0	0.0	0.0	0.25	0.87	0.17
42666	BRD-K27737647	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42971	BRD-K27737647	HT29	10 uM	6 h	-0.24	-0.99	0.14	0.28	0.99	0.39
43312	BRD-K27737647	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.27	0.95	0.32
43532	BRD-K27737647	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
43830	BRD-K27737647	PHH	10 uM	24 h	0.24	0.99	0.09	-0.3	-1.01	0.58
44101	BRD-K27737647	SKB	10 uM	24 h	0.0	0.0	0.0	0.28	0.97	0.36
97276	BRD-K27737647	HAP1	3.33 uM	24 h	-0.27	-1.13	0.4	-0.28	-0.96	0.43
97367	BRD-K27737647	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99792	BRD-K27737647	U2OS	10 uM	6 h	0.23	0.95	0.06	0.35	1.24	1.26

Summary