CMap Candidate Details
Structure:
| CMap ID: | C00257 |
| Pert ID: | BRD-K32285926 |
| Compound Name: | AMG-208 |
| Targets: | MET |
| MoA: | tyrosine kinase inhibitor |
| SMILES: | COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 120518 | BRD-K32285926 | A375 | 10 uM | 24 h | 0.22 | 0.9 | 0.02 | 0.24 | 0.84 | 0.13 |
| 120553 | BRD-K32285926 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.21 | -0.71 | 0.04 |
| 120593 | BRD-K32285926 | HA1E | 3.33 uM | 24 h | 0.18 | 0.74 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120617 | BRD-K32285926 | HELA | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120653 | BRD-K32285926 | HT29 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.01 | 0.56 |
| 120704 | BRD-K32285926 | JURKAT | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120775 | BRD-K32285926 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120810 | BRD-K32285926 | YAPC | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.27 | -0.92 | 0.33 |
| 129053 | BRD-K32285926 | MCF??7.00 | 0.74 uM | 24 h | -0.37 | -1.52 | 1.43 | -0.25 | -0.86 | 0.21 |