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CMap Candidate Details

Structure:
CMap ID: C02623
Pert ID: BRD-K44771174
Compound Name: ibutamoren
Targets: GHR|GHSR
MoA: growth hormone secretagogue receptor agonist
SMILES: CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CN(c3ccccc23)S(C)(=O)=O)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124648 BRD-K44771174 HELA 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
124751 BRD-K44771174 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124778 BRD-K44771174 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124824 BRD-K44771174 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124868 BRD-K44771174 THP1 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
124905 BRD-K44771174 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132656 BRD-K44771174 A375 2.22 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.73
132678 BRD-K44771174 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132712 BRD-K44771174 HA1E 0.74 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
132738 BRD-K44771174 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132804 BRD-K44771174 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132823 BRD-K44771174 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132855 BRD-K44771174 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).