CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02636
Pert ID:	BRD-K73290745
Compound Name:	ICI-199441
Targets:	CYP2D6\|OPRD1\|OPRK1\|OPRM1\|UTS2R
MoA:	opioid receptor agonist
SMILES:	CN([C@H](CN1CCCC1)c1ccccc1)C(=O)Cc1ccc(Cl)c(Cl)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4249	BRD-K73290745	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
4479	BRD-K73290745	HCC515	10 uM	24 h	-0.19	-0.78	0.0	0.35	1.23	1.19
4717	BRD-K73290745	PC3	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.06	0.72
5122	BRD-K73290745	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44438	BRD-K73290745	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44610	BRD-K73290745	A549	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.26
45016	BRD-K73290745	ASC	10 uM	24 h	-0.17	-0.7	0.0	0.0	0.0	0.0
45309	BRD-K73290745	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45569	BRD-K73290745	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45716	BRD-K73290745	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46131	BRD-K73290745	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46445	BRD-K73290745	PHH	10 uM	24 h	0.29	1.22	0.48	-0.25	-0.84	0.18
46770	BRD-K73290745	SKB	10 uM	24 h	0.0	0.0	0.0	-0.2	-0.68	0.02
99444	BRD-K73290745	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary