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CMap Candidate Details

Structure:
CMap ID: C02650
Pert ID: BRD-K62627508
Compound Name: idasanutlin
Targets: MDM2|TP53
MoA: MDM inhibitor
SMILES: COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124930 BRD-K62627508 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124958 BRD-K62627508 A549 3.33 uM 24 h -0.31 -1.27 0.74 -0.32 -1.09 0.83
125050 BRD-K62627508 HT29 10 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
125093 BRD-K62627508 MCF??7.00 1.11 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
125102 BRD-K62627508 MDAMB231 10 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
125128 BRD-K62627508 PC3 3.33 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
125149 BRD-K62627508 THP1 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.05
125198 BRD-K62627508 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133008 BRD-K62627508 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133035 BRD-K62627508 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133084 BRD-K62627508 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133142 BRD-K62627508 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.15
133190 BRD-K62627508 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).