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CMap Candidate Details

Structure:
CMap ID: C02683
Pert ID: BRD-K38436528
Compound Name: imipramine
Targets: ADRA1A|ADRA1B|ADRA1D|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD5|HRH1|HTR1A|HTR2A|HTR2C|HTR6|HTR7|KCND2|KCND3|KCNH1|KCNH2|SLC6A2|SLC6A3|SLC6A4
MoA: norepinephrine reputake inhibitor; serotonin reuptake inhibitor
SMILES: CN(C)CCCN1c2ccccc2CCc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7649 BRD-K38436528 HCC515 10 uM 6 h -0.26 -1.08 0.29 0.26 0.92 0.24
8668 BRD-K38436528 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91012 BRD-K38436528 HUH7 12 uM 72 h 0.0 0.0 0.0 0.34 1.2 1.07
123451 BRD-K38436528 THP1 10 uM 24 h 0.2 0.85 0.0 -0.38 -1.29 1.53
123487 BRD-K38436528 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
131525 BRD-K38436528 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131541 BRD-K38436528 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131577 BRD-K38436528 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131619 BRD-K38436528 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131653 BRD-K38436528 HELA 0.25 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.43
131681 BRD-K38436528 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
131712 BRD-K38436528 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131765 BRD-K38436528 JURKAT 0.74 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
131815 BRD-K38436528 MCF10A 2.22 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
131845 BRD-K38436528 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.23
131883 BRD-K38436528 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
131913 BRD-K38436528 PC3 0.25 uM 24 h -0.37 -1.53 1.43 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).