CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02684
Pert ID:	BRD-K26657438
Compound Name:	imiquimod
Targets:	TLR7\|TLR8
MoA:	interferon inducer; toll-like receptor agonist
SMILES:	CC(C)Cn1cnc2c(N)nc3ccccc3c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9191	BRD-K26657438	A549	10 uM	6 h	0.32	1.34	0.89	-0.27	-0.92	0.33
9392	BRD-K26657438	AGS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
9703	BRD-K26657438	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
9948	BRD-K26657438	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
10202	BRD-K26657438	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.32
11454	BRD-K26657438	NCIH2073	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11739	BRD-K26657438	NCIH508	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12293	BRD-K26657438	NOMO1	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13245	BRD-K26657438	U937	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.08	0.81
13463	BRD-K26657438	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91433	BRD-K26657438	HUH7	15 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
98877	BRD-K26657438	NEU	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.05
99134	BRD-K26657438	NPC	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.86
117331	BRD-K26657438	A375	1.11 uM	24 h	-0.23	-0.97	0.11	-0.33	-1.1	0.86
117500	BRD-K26657438	HEPG2	0.125 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
117544	BRD-K26657438	HT29	1.11 uM	24 h	-0.23	-0.94	0.08	0.0	0.0	0.0
117587	BRD-K26657438	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120068	BRD-K26657438	HELA	10 uM	3 h	0.0	0.0	0.0	0.33	1.18	0.98
128842	BRD-K26657438	PC3	2.22 uM	24 h	-0.18	-0.75	0.0	0.0	0.0	0.0
128861	BRD-K26657438	YAPC	0.74 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.3

Summary