CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02696
Pert ID:	BRD-A95869247
Compound Name:	indapamide
Targets:	KCNE1\|KCNQ1\|SLC12A3
MoA:	thiazide diuretic
SMILES:	CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
8791	BRD-A95869247	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50321	BRD-A95869247	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.22	-0.73	0.05
91435	BRD-A95869247	HUH7	10 uM	72 h	0.23	0.96	0.08	0.0	0.0	0.0
100416	BRD-A95869247	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
128135	BRD-A95869247	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128185	BRD-A95869247	HT29	10 uM	24 h	-0.27	-1.14	0.42	0.0	0.0	0.0
128216	BRD-A95869247	MCF10A	0.125 uM	24 h	0.23	0.94	0.06	0.42	1.48	2.24
128295	BRD-A95869247	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135756	BRD-A95869247	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135805	BRD-A95869247	HA1E	0.74 uM	24 h	0.0	0.0	0.0	-0.23	-0.79	0.1
135846	BRD-A95869247	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135890	BRD-A95869247	HELA	2.22 uM	24 h	0.29	1.19	0.42	0.0	0.0	0.0
135979	BRD-A95869247	JURKAT	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136025	BRD-A95869247	MCF??7.00	2.22 uM	24 h	-0.17	-0.71	0.0	0.22	0.78	0.07
136055	BRD-A95869247	PC3	2.22 uM	24 h	0.24	1.01	0.12	0.25	0.9	0.22
136086	BRD-A95869247	THP1	2.22 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.86
136125	BRD-A95869247	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary