CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02713
Pert ID:	BRD-K76953762
Compound Name:	indoramin
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2B\|ADRA2C
MoA:	adrenergic receptor antagonist
SMILES:	O=C(NC1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
127023	BRD-K76953762	A375	3.33 uM	24 h	-0.29	-1.21	0.6	0.29	1.02	0.49
127047	BRD-K76953762	HA1E	0.04 uM	24 h	0.21	0.88	0.02	0.0	0.0	0.0
127071	BRD-K76953762	HEK293	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127105	BRD-K76953762	HELA	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127141	BRD-K76953762	HT29	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
127166	BRD-K76953762	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	0.23	0.81	0.09
127245	BRD-K76953762	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127284	BRD-K76953762	THP1	0.125 uM	24 h	0.21	0.87	0.01	-0.17	-0.57	0.0
127320	BRD-K76953762	YAPC	0.04 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.55
135048	BRD-K76953762	A549	0.03 uM	24 h	-0.25	-1.03	0.2	0.26	0.93	0.26
135209	BRD-K76953762	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	-0.37	-1.23	1.28
135232	BRD-K76953762	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135272	BRD-K76953762	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary