CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02715
Pert ID:	BRD-K93779381
Compound Name:	ingenol-mebutate
Targets:	PRKCA\|PRKCB\|PRKCD\|PRKCE\|PRKCG
MoA:	PKC activator
SMILES:	C\C=C(\C)C(=O)O[C@H]1C(C)=C[C@@]23[C@H](C)C[C@@H]4[C@H]([C@H](C=C(CO)[C@@H](O)[C@]12O)C3=O)C4(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
128104	BRD-K93779381	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128182	BRD-K93779381	HT29	0.04 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.96
128208	BRD-K93779381	MCF10A	0.125 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09
128255	BRD-K93779381	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.88
128287	BRD-K93779381	MDAMB231	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128330	BRD-K93779381	PC3	0.04 uM	24 h	0.26	1.08	0.21	0.0	0.0	0.0
128347	BRD-K93779381	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135771	BRD-K93779381	A549	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135797	BRD-K93779381	HA1E	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135842	BRD-K93779381	HEK293	0.74 uM	24 h	0.21	0.86	0.01	0.0	0.0	0.0
135882	BRD-K93779381	HELA	0.08 uM	24 h	0.0	0.0	0.0	-0.5	-1.7	15.65
135971	BRD-K93779381	JURKAT	0.08 uM	24 h	-0.23	-0.95	0.09	-0.4	-1.33	1.74
136117	BRD-K93779381	YAPC	0.03 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.25

Summary