CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02741
Pert ID:	BRD-K84892605
Compound Name:	IOWH032
Targets:	CFTR
MoA:	CFTR channel antagonist
SMILES:	Oc1c(Br)cc(cc1Br)-c1noc(n1)C(=O)NCc1ccc(Oc2ccccc2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125969	BRD-K84892605	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125989	BRD-K84892605	A549	0.125 uM	24 h	0.0	0.0	0.0	0.3	1.07	0.63
126014	BRD-K84892605	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.52
126097	BRD-K84892605	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.36	2.02
126145	BRD-K84892605	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126198	BRD-K84892605	MCF10A	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126270	BRD-K84892605	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.29	1.02	0.46
126316	BRD-K84892605	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126347	BRD-K84892605	YAPC	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134119	BRD-K84892605	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.29	1.02	0.48
134161	BRD-K84892605	HELA	0.01 uM	24 h	0.22	0.9	0.02	0.0	0.0	0.0
134192	BRD-K84892605	HT29	0.03 uM	24 h	0.19	0.79	0.0	0.0	0.0	0.0
134239	BRD-K84892605	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.48
134272	BRD-K84892605	MDAMB231	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary