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CMap Candidate Details

Structure:
CMap ID: C02748
Pert ID: BRD-K93468883
Compound Name: IPI-145
Targets: PIK3CA|PIK3CB|PIK3CD|PIK3CG
MoA: PI3K inhibitor
SMILES: C[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
74 BRD-K93468883 BJAB 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
106 BRD-K93468883 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
140 BRD-K93468883 K562 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
199 BRD-K93468883 KMS34 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
238 BRD-K93468883 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
278 BRD-K93468883 OCILY10 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
300 BRD-K93468883 OCILY19 0.01 uM 24 h 0.3 1.25 0.56 0.0 0.0 0.0
347 BRD-K93468883 OCILY3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
395 BRD-K93468883 SKMEL5 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
412 BRD-K93468883 THP1 2.5 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
452 BRD-K93468883 TMD8 2.5 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.01
95828 BRD-K93468883 A375 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95864 BRD-K93468883 NPC 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95884 BRD-K93468883 MCF??7.00 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95943 BRD-K93468883 YAPC 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95956 BRD-K93468883 A549 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95968 BRD-K93468883 PC3 0.5 uM 6 h -0.26 -1.08 0.3 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).