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CMap Candidate Details

Structure:
CMap ID: C02756
Pert ID: BRD-K08547377
Compound Name: irinotecan
Targets: TOP1|TOP1MT
MoA: topoisomerase inhibitor
SMILES: CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24747 BRD-K08547377 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.81
25325 BRD-K08547377 VCAP 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
39090 BRD-K08547377 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39626 BRD-K08547377 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40750 BRD-K08547377 NEU 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.75
41049 BRD-K08547377 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41378 BRD-K08547377 SKB 10 uM 24 h 0.21 0.86 0.01 0.3 1.06 0.58
51586 BRD-K08547377 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116103 BRD-K08547377 HCC515 10 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
116148 BRD-K08547377 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121179 BRD-K08547377 A549 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
121264 BRD-K08547377 HELA 10 uM 3 h 0.0 0.0 0.0 0.26 0.91 0.23
121342 BRD-K08547377 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129289 BRD-K08547377 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129350 BRD-K08547377 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).