CMap Candidate Details
Structure:
| CMap ID: | C02769 |
| Pert ID: | BRD-A93353767 |
| Compound Name: | isoconazole |
| Targets: | CYP17A1 |
| MoA: | fungal lanosterol demethylase inhibitor |
| SMILES: | Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 100400 | BRD-A93353767 | U2OS | 4 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128375 | BRD-A93353767 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128425 | BRD-A93353767 | HEK293 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128497 | BRD-A93353767 | HT29 | 3.33 uM | 24 h | -0.26 | -1.09 | 0.33 | 0.0 | 0.0 | 0.0 |
| 128535 | BRD-A93353767 | JURKAT | 10 uM | 24 h | 0.23 | 0.97 | 0.08 | 0.28 | 1.0 | 0.43 |
| 128587 | BRD-A93353767 | MCF10A | 10 uM | 24 h | -0.31 | -1.27 | 0.74 | 0.29 | 1.02 | 0.48 |
| 128628 | BRD-A93353767 | MDAMB231 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128675 | BRD-A93353767 | PC3 | 0.37 uM | 24 h | -0.33 | -1.37 | 1.08 | 0.0 | 0.0 | 0.0 |
| 128708 | BRD-A93353767 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.08 | 0.79 |
| 136169 | BRD-A93353767 | A375 | 0.03 uM | 24 h | 0.26 | 1.07 | 0.2 | -0.27 | -0.91 | 0.3 |
| 136214 | BRD-A93353767 | HA1E | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136255 | BRD-A93353767 | HELA | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136335 | BRD-A93353767 | MCF??7.00 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 136382 | BRD-A93353767 | YAPC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.17 | 1.12 |