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CMap Candidate Details

Structure:
CMap ID: C00278
Pert ID: BRD-K97181089
Compound Name: amiloride
Targets: AOC1|ASIC1|ASIC2|ASIC3|PKD2|PKD2L1|PLAU|SCNN1A|SCNN1B|SCNN1D|SCNN1G|SLC9A1|TRPC7|TRPV2
MoA: sodium channel blocker
SMILES: NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3304 BRD-K97181089 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3910 BRD-K97181089 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13893 BRD-K97181089 A375 10 uM 24 h -0.26 -1.06 0.26 0.3 1.08 0.65
14363 BRD-K97181089 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
14554 BRD-K97181089 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.62 0.0
45058 BRD-K97181089 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45342 BRD-K97181089 HEPG2 10 uM 6 h 0.19 0.77 0.0 0.0 0.0 0.0
46167 BRD-K97181089 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46482 BRD-K97181089 PHH 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
46812 BRD-K97181089 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91028 BRD-K97181089 HUH7 15 uM 72 h 0.19 0.78 0.0 -0.28 -0.93 0.35
128169 BRD-K97181089 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128224 BRD-K97181089 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128303 BRD-K97181089 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
128355 BRD-K97181089 THP1 0.125 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
135898 BRD-K97181089 HELA 2.22 uM 24 h 0.25 1.04 0.16 0.33 1.16 0.9
135943 BRD-K97181089 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.52
135987 BRD-K97181089 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
136030 BRD-K97181089 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136061 BRD-K97181089 PC3 0.03 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
136133 BRD-K97181089 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).