CMap Candidate Details
Structure:
| CMap ID: | C02789 |
| Pert ID: | BRD-K82225283 |
| Compound Name: | isosorbide-mononitrate |
| Targets: | GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3 |
| MoA: | nitric oxide stimulant |
| SMILES: | O[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)O[N+]([O-])=O |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 52338 | BRD-K82225283 | PC3 | 10 uM | 24 h | -0.2 | -0.83 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126002 | BRD-K82225283 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126030 | BRD-K82225283 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126078 | BRD-K82225283 | HUVEC | 0.04 uM | 24 h | 0.31 | 1.28 | 0.64 | 0.0 | 0.0 | 0.0 |
| 126123 | BRD-K82225283 | JURKAT | 0.125 uM | 24 h | -0.26 | -1.09 | 0.32 | 0.0 | 0.0 | 0.0 |
| 126176 | BRD-K82225283 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 126295 | BRD-K82225283 | THP1 | 10 uM | 24 h | 0.24 | 0.99 | 0.1 | -0.25 | -0.84 | 0.18 |
| 134004 | BRD-K82225283 | A375 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134035 | BRD-K82225283 | A549 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134097 | BRD-K82225283 | HEK293 | 0.74 uM | 24 h | -0.35 | -1.46 | 1.43 | 0.0 | 0.0 | 0.0 |
| 134180 | BRD-K82225283 | HT29 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.37 | 1.3 | 1.49 |
| 134226 | BRD-K82225283 | MCF??7.00 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.27 | 0.94 | 0.29 |
| 134255 | BRD-K82225283 | MDAMB231 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 134310 | BRD-K82225283 | YAPC | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |