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CMap Candidate Details

Structure:
CMap ID: C02818
Pert ID: BRD-K78659596
Compound Name: ixazomib
Targets:
MoA: proteasome inhibitor
SMILES: CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1341 BRD-K78659596 U2OS 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9511 BRD-K78659596 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9816 BRD-K78659596 H1299 10 uM 6 h 0.21 0.89 0.02 0.0 0.0 0.0
10259 BRD-K78659596 HCC515 10 uM 6 h 0.19 0.8 0.0 0.0 0.0 0.0
10598 BRD-K78659596 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10851 BRD-K78659596 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11299 BRD-K78659596 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11577 BRD-K78659596 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
11840 BRD-K78659596 NCIH508 10 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
12135 BRD-K78659596 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
12384 BRD-K78659596 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12439 BRD-K78659596 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12872 BRD-K78659596 SW480 10 uM 6 h 0.29 1.22 0.48 0.0 0.0 0.0
13362 BRD-K78659596 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13502 BRD-K78659596 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97491 BRD-K78659596 NKDBA 3.33 uM 24 h 0.26 1.07 0.2 -0.29 -0.99 0.5
127034 BRD-K78659596 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127054 BRD-K78659596 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.22 0.8 0.08
127080 BRD-K78659596 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127171 BRD-K78659596 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
127295 BRD-K78659596 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135062 BRD-K78659596 A549 0.25 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
135133 BRD-K78659596 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135153 BRD-K78659596 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
135221 BRD-K78659596 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
135288 BRD-K78659596 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135335 BRD-K78659596 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).