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CMap Candidate Details

Structure:
CMap ID: C02819
Pert ID: BRD-A66419424
Compound Name: ixazomib-citrate
Targets:
MoA: proteasome inhibitor
SMILES: CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125085 BRD-A66419424 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125183 BRD-A66419424 THP1 0.125 uM 24 h -0.25 -1.04 0.22 0.0 0.0 0.0
125222 BRD-A66419424 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
132987 BRD-A66419424 A375 0.03 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
133002 BRD-A66419424 A549 0.25 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
133023 BRD-A66419424 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133073 BRD-A66419424 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133100 BRD-A66419424 HELA 0.03 uM 24 h 0.25 1.06 0.18 -0.38 -1.27 1.43
133130 BRD-A66419424 HT29 0.03 uM 24 h 0.24 1.0 0.11 0.23 0.8 0.08
133179 BRD-A66419424 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133242 BRD-A66419424 MCF??7.00 0.25 uM 24 h 0.2 0.85 0.0 0.0 0.0 0.0
133271 BRD-A66419424 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133302 BRD-A66419424 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).