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CMap Candidate Details

Structure:
CMap ID: C02835
Pert ID: BRD-K02123250
Compound Name: JNJ-38877605
Targets: MET
MoA: tyrosine kinase inhibitor
SMILES: Cn1cc(cn1)-c1ccc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50326 BRD-K02123250 HCC515 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 1.0
50899 BRD-K02123250 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51116 BRD-K02123250 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
91793 BRD-K02123250 HS578T 0.08 uM 6 h 0.22 0.92 0.04 0.24 0.86 0.16
91909 BRD-K02123250 MDAMB231 2.22 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.46
91954 BRD-K02123250 SKBR3 2.22 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.85
94509 BRD-K02123250 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94539 BRD-K02123250 CD34 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94630 BRD-K02123250 HEK293 10 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
94733 BRD-K02123250 HME1 0.12 uM 24 h 0.27 1.13 0.28 -0.22 -0.75 0.06
94879 BRD-K02123250 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94927 BRD-K02123250 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94967 BRD-K02123250 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95006 BRD-K02123250 NEU 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95071 BRD-K02123250 NPC 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
95152 BRD-K02123250 SHSY5Y 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95202 BRD-K02123250 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122848 BRD-K02123250 A549 3.33 uM 24 h 0.3 1.25 0.54 0.0 0.0 0.0
122943 BRD-K02123250 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123188 BRD-K02123250 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131214 BRD-K02123250 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131282 BRD-K02123250 HA1E 0.03 uM 24 h 0.27 1.14 0.31 -0.28 -0.95 0.41
131328 BRD-K02123250 HT29 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
131364 BRD-K02123250 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.85
131501 BRD-K02123250 YAPC 0.08 uM 24 h -0.21 -0.86 0.02 -0.31 -1.06 0.73
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).