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CMap Candidate Details

Structure:
CMap ID: C02849
Pert ID: BRD-K53328210
Compound Name: JW-55
Targets: TNKS|TNKS2
MoA: tankyrase inhibitor
SMILES: COc1ccc(cc1)C1(CNC(=O)c2ccc(NC(=O)c3ccco3)cc2)CCOCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
93616 BRD-K53328210 A549 10 uM 24 h -0.25 -1.04 0.22 0.0 0.0 0.0
93652 BRD-K53328210 ASC 0.37 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.89
93712 BRD-K53328210 CD34 0.37 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
93758 BRD-K53328210 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.47
93792 BRD-K53328210 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93839 BRD-K53328210 HEK293 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93885 BRD-K53328210 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93925 BRD-K53328210 HEPG2 10 uM 24 h 0.24 0.98 0.09 -0.24 -0.8 0.11
93960 BRD-K53328210 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94023 BRD-K53328210 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
94061 BRD-K53328210 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
94103 BRD-K53328210 NEU 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94175 BRD-K53328210 NPC 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
94192 BRD-K53328210 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94236 BRD-K53328210 SHSY5Y 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94287 BRD-K53328210 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94336 BRD-K53328210 THP1 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.14
94380 BRD-K53328210 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
96832 BRD-K53328210 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).