CMap Candidate Details
Structure:
| CMap ID: | C02852 |
| Pert ID: | BRD-K75664313 |
| Compound Name: | JW-74 |
| Targets: | TNKS|TNKS2 |
| MoA: | WNT signaling inhibitor; tankyrase inhibitor |
| SMILES: | COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(C)cc2)nnc1-c1ccncc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 115980 | BRD-K75664313 | A375 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 116021 | BRD-K75664313 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 116060 | BRD-K75664313 | HA1E | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 116102 | BRD-K75664313 | HCC515 | 10 uM | 24 h | 0.21 | 0.88 | 0.02 | 0.0 | 0.0 | 0.0 |
| 116147 | BRD-K75664313 | HEPG2 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 116193 | BRD-K75664313 | HT29 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.89 | 0.26 |
| 116230 | BRD-K75664313 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.18 | 1.15 |
| 116270 | BRD-K75664313 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.25 | 0.87 | 0.17 |