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CMap Candidate Details

Structure:
CMap ID: C02853
Pert ID: BRD-K05464208
Compound Name: JX-401
Targets: MAPK14
MoA: p38 MAPK inhibitor
SMILES: COc1cc(SC)ccc1C(=O)N1CCC(Cc2ccccc2)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1728 BRD-K05464208 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2071 BRD-K05464208 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.19
2365 BRD-K05464208 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41709 BRD-K05464208 A375 10 uM 6 h -0.25 -1.03 0.19 0.0 0.0 0.0
42046 BRD-K05464208 A549 10 uM 6 h 0.24 1.02 0.12 0.29 1.03 0.51
42269 BRD-K05464208 ASC 10 uM 24 h 0.27 1.12 0.26 -0.29 -0.97 0.45
42605 BRD-K05464208 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42909 BRD-K05464208 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43151 BRD-K05464208 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43464 BRD-K05464208 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43771 BRD-K05464208 PHH 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
44050 BRD-K05464208 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88426 BRD-K05464208 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
99997 BRD-K05464208 U2OS 10 uM 6 h 0.27 1.13 0.28 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).