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CMap Candidate Details

Structure:
CMap ID: C02873
Pert ID: BRD-K49671696
Compound Name: ketanserin
Targets: ADRA1A|ADRA1B|ADRA1D|DRD1|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR5A|HTR7|SLC18A1|SLC18A2
MoA: serotonin receptor antagonist
SMILES: Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3218 BRD-K49671696 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3816 BRD-K49671696 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39709 BRD-K49671696 ASC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
40014 BRD-K49671696 HEPG2 10 uM 6 h 0.32 1.32 0.82 0.0 0.0 0.0
41130 BRD-K49671696 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41465 BRD-K49671696 SKB 10 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.87
91340 BRD-K49671696 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99607 BRD-K49671696 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
125332 BRD-K49671696 HEK293 0.125 uM 24 h -0.29 -1.21 0.59 0.0 0.0 0.0
125459 BRD-K49671696 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
125502 BRD-K49671696 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125555 BRD-K49671696 YAPC 10 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
133348 BRD-K49671696 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
133371 BRD-K49671696 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133400 BRD-K49671696 HA1E 0.01 uM 24 h 0.27 1.13 0.3 0.0 0.0 0.0
133435 BRD-K49671696 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133464 BRD-K49671696 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
133491 BRD-K49671696 JURKAT 0.08 uM 24 h -0.2 -0.83 0.0 0.21 0.73 0.03
133528 BRD-K49671696 MCF10A 0.03 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
133567 BRD-K49671696 MDAMB231 0.03 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
133612 BRD-K49671696 THP1 0.25 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).