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CMap Candidate Details

Structure:
CMap ID: C02908
Pert ID: BRD-K21718444
Compound Name: KW-2449
Targets: ABL1|AURKA|AURKB|FLT3
MoA: Abl kinase inhibitor; Aurora kinase inhibitor; FLT3 inhibitor
SMILES: O=C(N1CCNCC1)c1ccc(cc1)\C=C\c1n[nH]c2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92892 BRD-K21718444 A549 10 uM 24 h -0.19 -0.78 0.0 -0.22 -0.73 0.04
92956 BRD-K21718444 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92990 BRD-K21718444 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93078 BRD-K21718444 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93166 BRD-K21718444 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93215 BRD-K21718444 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93272 BRD-K21718444 JURKAT 10 uM 24 h 0.2 0.85 0.01 -0.31 -1.04 0.66
93312 BRD-K21718444 MCF10A 10 uM 24 h -0.28 -1.17 0.49 -0.35 -1.18 1.14
93353 BRD-K21718444 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
93392 BRD-K21718444 NPC 1.11 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
93480 BRD-K21718444 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93539 BRD-K21718444 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120870 BRD-K21718444 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120914 BRD-K21718444 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121020 BRD-K21718444 HT29 10 uM 24 h 0.32 1.35 0.91 0.0 0.0 0.0
121051 BRD-K21718444 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
121082 BRD-K21718444 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121119 BRD-K21718444 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129167 BRD-K21718444 HELA 2.22 uM 3 h 0.0 0.0 0.0 -0.26 -0.86 0.21
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).