CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02909
Pert ID:	BRD-K41213548
Compound Name:	KW-2478
Targets:
MoA:	HSP inhibitor
SMILES:	CCc1c(O)cc(O)c(C(=O)c2ccc(OCCN3CCOCC3)c(OC)c2)c1CC(=O)N(CCOC)CCOC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1244	BRD-K41213548	A549	1.11 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
1286	BRD-K41213548	MCF??7.00	1.11 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
1384	BRD-K41213548	U2OS	10 uM	6 h	0.0	0.0	0.0	0.3	1.06	0.59
123314	BRD-K41213548	HELA	10 uM	24 h	-0.22	-0.92	0.06	0.0	0.0	0.0
123343	BRD-K41213548	HT29	0.37 uM	24 h	-0.23	-0.94	0.08	0.0	0.0	0.0
123367	BRD-K41213548	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123424	BRD-K41213548	PC3	3.33 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
123461	BRD-K41213548	THP1	3.33 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
131528	BRD-K41213548	A375	2.22 uM	24 h	0.29	1.2	0.42	0.27	0.97	0.35
131590	BRD-K41213548	HA1E	2.22 uM	24 h	-0.24	-0.99	0.14	-0.26	-0.88	0.25
131631	BRD-K41213548	HEK293	2.22 uM	24 h	-0.28	-1.17	0.48	-0.26	-0.89	0.27
131729	BRD-K41213548	HUVEC	2.22 uM	24 h	-0.26	-1.1	0.34	0.0	0.0	0.0
131783	BRD-K41213548	JURKAT	2.22 uM	24 h	-0.21	-0.89	0.04	0.0	0.0	0.0
131895	BRD-K41213548	MDAMB231	2.22 uM	24 h	0.18	0.73	0.0	0.0	0.0	0.0
131957	BRD-K41213548	YAPC	2.22 uM	24 h	-0.2	-0.83	0.0	0.32	1.15	0.88

Summary