CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C02959
Pert ID:	BRD-K05528470
Compound Name:	L-745870
Targets:	DRD1\|DRD2\|DRD3\|DRD4\|HTR1A\|HTR2A\|HTR6\|HTR7
MoA:	dopamine receptor antagonist
SMILES:	Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2980	BRD-K05528470	HA1E	10 uM	6 h	0.19	0.79	0.0	0.31	1.09	0.67
3133	BRD-K05528470	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	0.98
3462	BRD-K05528470	PC3	10 uM	24 h	0.29	1.2	0.43	-0.25	-0.83	0.16
3716	BRD-K05528470	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39087	BRD-K05528470	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39295	BRD-K05528470	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39621	BRD-K05528470	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39942	BRD-K05528470	HEPG2	10 uM	6 h	0.17	0.72	0.0	0.0	0.0	0.0
40222	BRD-K05528470	HT29	10 uM	6 h	0.0	0.0	0.0	-0.33	-1.12	0.94
40451	BRD-K05528470	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40745	BRD-K05528470	NEU	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.87	0.23
41046	BRD-K05528470	NPC	10 uM	24 h	0.26	1.07	0.19	0.0	0.0	0.0
41373	BRD-K05528470	SKB	10 uM	24 h	-0.24	-1.01	0.16	-0.18	-0.61	0.0

Summary