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CMap Candidate Details

Structure:
CMap ID: C02965
Pert ID: BRD-A07440155
Compound Name: labetalol
Targets: ADRA1A|ADRA1B|ADRA1D|ADRB1|ADRB2
MoA: adrenergic receptor antagonist
SMILES: CC(CCc1ccccc1)NCC(O)c1ccc(O)c(c1)C(N)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5492 BRD-A07440155 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5819 BRD-A07440155 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37213 BRD-A07440155 A549 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.68
37436 BRD-A07440155 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38290 BRD-A07440155 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38599 BRD-A07440155 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38815 BRD-A07440155 SKB 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
51087 BRD-A07440155 VCAP 10 uM 6 h 0.28 1.18 0.39 -0.17 -0.56 0.0
122556 BRD-A07440155 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
122608 BRD-A07440155 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122643 BRD-A07440155 HEK293 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
122689 BRD-A07440155 HT29 0.04 uM 24 h -0.27 -1.11 0.37 0.0 0.0 0.0
122736 BRD-A07440155 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130978 BRD-A07440155 HELA 0.03 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
131058 BRD-A07440155 HUVEC 0.03 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
131093 BRD-A07440155 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.39 1.39 2.17
131130 BRD-A07440155 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131157 BRD-A07440155 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131192 BRD-A07440155 YAPC 2.22 uM 24 h 0.17 0.7 0.0 -0.34 -1.16 1.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).