CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00298
Pert ID:	BRD-K53737926
Compound Name:	amitriptyline
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRB1\|ADRB2\|ADRB3\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|HRH1\|HRH2\|HRH4\|HTR1A\|HTR1B\|HTR1D\|HTR2A\|HTR2C\|HTR6\|HTR7\|KCNA1\|KCND2\|KCND3\|KCNQ2\|KCNQ3\|NTRK1\|NTRK2\|OPRD1\|OPRK1\|OPRM1\|SIGMAR1\|SLC6A2\|SLC6A4
MoA:	norepinephrine inhibitor; norepinephrine reuptake inhibitor; serotonin receptor antagonist; serotonin norepinephrine reuptake inhibitor (SNRI)
SMILES:	CN(C)CCC=C1c2ccccc2CCc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1440	BRD-K53737926	NPC	25 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.1
4443	BRD-K53737926	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
4695	BRD-K53737926	PC3	10 uM	24 h	0.3	1.23	0.51	0.23	0.82	0.1
4938	BRD-K53737926	VCAP	10 uM	24 h	-0.28	-1.16	0.48	-0.31	-1.03	0.64
37298	BRD-K53737926	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37691	BRD-K53737926	ASC	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.06	0.74
37921	BRD-K53737926	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.25	0.88	0.19
38746	BRD-K53737926	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99648	BRD-K53737926	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
121567	BRD-K53737926	A375	10 uM	24 h	0.0	0.0	0.0	0.41	1.44	2.21
121609	BRD-K53737926	HA1E	10 uM	24 h	0.0	0.0	0.0	0.31	1.11	0.72
121643	BRD-K53737926	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121663	BRD-K53737926	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121685	BRD-K53737926	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121709	BRD-K53737926	YAPC	10 uM	24 h	0.27	1.13	0.3	0.0	0.0	0.0

Summary