CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00299
Pert ID:	BRD-K29530284
Compound Name:	amlexanox
Targets:	FGF1\|IL3\|PDE4A\|PDE4B\|PDE4C\|PDE4D\|S100A12\|S100A13
MoA:	histamine receptor modulator
SMILES:	CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25348	BRD-K29530284	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121891	BRD-K29530284	A375	10 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.42
122043	BRD-K29530284	HUVEC	10 uM	24 h	-0.23	-0.95	0.09	0.0	0.0	0.0
122089	BRD-K29530284	MCF10A	10 uM	24 h	-0.25	-1.06	0.26	-0.31	-1.03	0.65
122137	BRD-K29530284	MDAMB231	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.87
122188	BRD-K29530284	THP1	1.11 uM	24 h	0.19	0.8	0.0	0.32	1.13	0.82
130199	BRD-K29530284	A549	0.03 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.17
130223	BRD-K29530284	HA1E	0.01 uM	24 h	-0.2	-0.84	0.0	0.0	0.0	0.0
130255	BRD-K29530284	HEK293	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130285	BRD-K29530284	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130316	BRD-K29530284	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130344	BRD-K29530284	JURKAT	0.25 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.3
130428	BRD-K29530284	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130477	BRD-K29530284	PC3	0.74 uM	24 h	0.0	0.0	0.0	-0.24	-0.8	0.12
130518	BRD-K29530284	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary