CMap Candidate Details
Structure:
| CMap ID: | C02992 |
| Pert ID: | BRD-K08248804 |
| Compound Name: | LCL-161 |
| Targets: | BIRC2|XIAP |
| MoA: | XIAP inhibitor |
| SMILES: | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1ccc(F)cc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 90830 | BRD-K08248804 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121143 | BRD-K08248804 | A375 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.96 | 0.44 |
| 121180 | BRD-K08248804 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.22 | -0.73 | 0.04 |
| 121215 | BRD-K08248804 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121248 | BRD-K08248804 | HELA | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121305 | BRD-K08248804 | PC3 | 1.11 uM | 24 h | 0.23 | 0.97 | 0.08 | 0.0 | 0.0 | 0.0 |
| 129290 | BRD-K08248804 | HT29 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129326 | BRD-K08248804 | MCF??7.00 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129363 | BRD-K08248804 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |