CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00300
Pert ID:	BRD-A22032524
Compound Name:	amlodipine
Targets:	CA1\|CACNA1B\|CACNA1C\|CACNA1D\|CACNA1F\|CACNA1S\|CACNA2D1\|CACNA2D3\|CACNB1\|CACNB2\|SMPD1
MoA:	calcium channel blocker
SMILES:	CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1226	BRD-A22032524	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
1291	BRD-A22032524	MCF??7.00	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
1392	BRD-A22032524	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
5506	BRD-A22032524	HCC515	10 uM	24 h	0.0	0.0	0.0	0.24	0.84	0.13
6125	BRD-A22032524	PC3	10 uM	24 h	0.17	0.72	0.0	0.27	0.97	0.34
6455	BRD-A22032524	VCAP	10 uM	6 h	0.23	0.98	0.09	0.3	1.08	0.64
37049	BRD-A22032524	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37455	BRD-A22032524	ASC	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.01
37792	BRD-A22032524	HEPG2	10 uM	6 h	0.32	1.32	0.84	0.0	0.0	0.0
38305	BRD-A22032524	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38608	BRD-A22032524	PHH	10 uM	24 h	0.22	0.92	0.04	0.0	0.0	0.0
38830	BRD-A22032524	SKB	10 uM	24 h	0.0	0.0	0.0	0.25	0.89	0.21
91029	BRD-A22032524	HUH7	8 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
120951	BRD-A22032524	HEK293	10 uM	24 h	-0.22	-0.9	0.05	0.0	0.0	0.0
120986	BRD-A22032524	HELA	10 uM	24 h	0.0	0.0	0.0	-0.45	-1.5	15.35
121017	BRD-A22032524	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121107	BRD-A22032524	YAPC	3.33 uM	24 h	0.0	0.0	0.0	-0.38	-1.27	1.39
129134	BRD-A22032524	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary