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CMap Candidate Details

Structure:
CMap ID: C03000
Pert ID: BRD-K04853698
Compound Name: LDN193189
Targets: ACVR1|BMPR1A
MoA: bone morphogenic protein inhibitor
SMILES: C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9343 BRD-K04853698 AGS 10 uM 6 h 0.0 0.0 0.0 0.36 1.27 1.34
9649 BRD-K04853698 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10446 BRD-K04853698 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10716 BRD-K04853698 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11399 BRD-K04853698 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.48 -1.61 15.65
11699 BRD-K04853698 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12715 BRD-K04853698 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13443 BRD-K04853698 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91955 BRD-K04853698 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91989 BRD-K04853698 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92015 BRD-K04853698 BT20 1.11 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
92065 BRD-K04853698 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
92095 BRD-K04853698 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92134 BRD-K04853698 HS578T 3.33 uM 24 h 0.18 0.75 0.0 -0.28 -0.95 0.4
92213 BRD-K04853698 MCF10A 1.11 uM 24 h 0.32 1.32 0.78 0.0 0.0 0.0
92252 BRD-K04853698 MCF??7.00 0.37 uM 24 h 0.24 1.01 0.11 0.0 0.0 0.0
92308 BRD-K04853698 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92337 BRD-K04853698 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119699 BRD-K04853698 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119747 BRD-K04853698 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.44
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).