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CMap Candidate Details

Structure:
CMap ID: C03001
Pert ID: BRD-K06593056
Compound Name: LE-135
Targets: RARB
MoA: retinoid receptor agonist
SMILES: CN1c2cc3c(cc2N=C(c2ccc(cc2)C(O)=O)c2ccccc12)C(C)(C)CCC3(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8902 BRD-K06593056 A375 20 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.75
9169 BRD-K06593056 A549 20 uM 6 h 0.0 0.0 0.0 -0.44 -1.49 15.35
9347 BRD-K06593056 AGS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9653 BRD-K06593056 H1299 20 uM 6 h 0.0 0.0 0.0 -0.38 -1.27 1.39
9916 BRD-K06593056 HA1E 20 uM 24 h -0.21 -0.88 0.03 -0.34 -1.15 1.07
10295 BRD-K06593056 HCC515 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10450 BRD-K06593056 HCT116 20 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.68
10935 BRD-K06593056 HT29 20 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
11171 BRD-K06593056 MCF??7.00 20 uM 24 h -0.3 -1.26 0.72 0.0 0.0 0.0
11404 BRD-K06593056 NCIH2073 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11974 BRD-K06593056 NCIH596 20 uM 6 h 0.31 1.28 0.64 0.33 1.17 0.92
12485 BRD-K06593056 PC3 20 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
12719 BRD-K06593056 SW480 20 uM 6 h 0.0 0.0 0.0 -0.4 -1.34 1.85
13005 BRD-K06593056 THP1 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13199 BRD-K06593056 U937 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13573 BRD-K06593056 VCAP 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37585 BRD-K06593056 ASC 10 uM 24 h 0.0 0.0 0.0 -0.45 -1.51 15.35
37867 BRD-K06593056 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.72
38420 BRD-K06593056 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38683 BRD-K06593056 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38907 BRD-K06593056 SKB 10 uM 24 h 0.21 0.88 0.01 0.0 0.0 0.0
100014 BRD-K06593056 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.18 1.14
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).