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CMap Candidate Details

Structure:
CMap ID: C03002
Pert ID: BRD-K05446112
Compound Name: ledipasvir
Targets:
MoA: HCV inhibitor
SMILES: COC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1c1ncc([nH]1)-c1ccc2-c3ccc(cc3C(F)(F)c2c1)-c1ccc2nc([nH]c2c1)[C@@H]1[C@H]2CC[C@H](C2)N1C(=O)[C@@H](NC(=O)OC)C(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122569 BRD-K05446112 A549 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
122625 BRD-K05446112 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122673 BRD-K05446112 HT29 10 uM 24 h 0.25 1.03 0.14 -0.31 -1.06 0.72
122706 BRD-K05446112 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122765 BRD-K05446112 MDAMB231 10 uM 24 h -0.23 -0.94 0.08 -0.2 -0.68 0.02
122787 BRD-K05446112 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130861 BRD-K05446112 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130906 BRD-K05446112 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130956 BRD-K05446112 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131028 BRD-K05446112 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
131077 BRD-K05446112 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131175 BRD-K05446112 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).