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CMap Candidate Details

Structure:
CMap ID: C03003
Pert ID: BRD-K78692225
Compound Name: leflunomide
Targets: AHR|DHODH|PTK2B
MoA: dihydroorotate dehydrogenase inhibitor; PDGFR tyrosine kinase receptor inhibitor
SMILES: Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1628 BRD-K78692225 HA1E 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
1973 BRD-K78692225 HCC515 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
2626 BRD-K78692225 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42477 BRD-K78692225 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
43954 BRD-K78692225 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44206 BRD-K78692225 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53328 BRD-K78692225 MCF10A 100 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.7
91470 BRD-K78692225 HUH7 12.5 uM 72 h 0.0 0.0 0.0 -0.46 -1.54 15.35
127078 BRD-K78692225 HEK293 3.33 uM 24 h 0.24 1.0 0.11 -0.26 -0.86 0.22
127118 BRD-K78692225 HELA 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
127153 BRD-K78692225 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127169 BRD-K78692225 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.32
127256 BRD-K78692225 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
127293 BRD-K78692225 THP1 0.37 uM 24 h -0.28 -1.15 0.43 0.19 0.69 0.01
135021 BRD-K78692225 A375 0.25 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
135061 BRD-K78692225 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135238 BRD-K78692225 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135286 BRD-K78692225 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135334 BRD-K78692225 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).