CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03006
Pert ID:	BRD-K39974922
Compound Name:	lenvatinib
Targets:	FLT4\|KDR
MoA:	FGFR inhibitor; KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES:	COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
123232	BRD-K39974922	A375	10 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.27
123261	BRD-K39974922	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123337	BRD-K39974922	HT29	10 uM	24 h	0.23	0.97	0.08	-0.3	-1.0	0.55
123364	BRD-K39974922	MCF10A	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.05
123418	BRD-K39974922	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123455	BRD-K39974922	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123491	BRD-K39974922	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131583	BRD-K39974922	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131623	BRD-K39974922	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131657	BRD-K39974922	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131719	BRD-K39974922	HUVEC	2.22 uM	24 h	-0.3	-1.24	0.64	0.0	0.0	0.0
131772	BRD-K39974922	JURKAT	0.08 uM	24 h	-0.21	-0.86	0.02	0.31	1.11	0.73
131852	BRD-K39974922	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131888	BRD-K39974922	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.38

Summary