CMap Candidate Details
Structure:
| CMap ID: | C03008 |
| Pert ID: | BRD-K62398570 |
| Compound Name: | lerisetron |
| Targets: | HTR3A |
| MoA: | serotonin receptor antagonist |
| SMILES: | C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 124573 | BRD-K62398570 | A375 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.26 | 0.91 | 0.23 |
| 124739 | BRD-K62398570 | MCF10A | 0.37 uM | 24 h | -0.2 | -0.81 | 0.0 | -0.21 | -0.72 | 0.04 |
| 124756 | BRD-K62398570 | MCF??7.00 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.19 | 1.15 |
| 124787 | BRD-K62398570 | MDAMB231 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124830 | BRD-K62398570 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124910 | BRD-K62398570 | YAPC | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132682 | BRD-K62398570 | A549 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132715 | BRD-K62398570 | HA1E | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.19 | 1.02 |
| 132744 | BRD-K62398570 | HEK293 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132783 | BRD-K62398570 | HELA | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.29 | 1.04 | 0.56 |
| 132807 | BRD-K62398570 | HT29 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.31 | 1.71 |
| 132828 | BRD-K62398570 | JURKAT | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132928 | BRD-K62398570 | THP1 | 0.25 uM | 24 h | 0.19 | 0.79 | 0.0 | 0.0 | 0.0 | 0.0 |