CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00301
Pert ID:	BRD-K15318383
Compound Name:	ammonium-glycyrrhizinate
Targets:	HSD11B1\|HSD11B2\|SLCO1B1\|SLCO1B3
MoA:	thrombin inhibitor
SMILES:	C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@]4(C)CC[C@H](O[C@H]5O[C@@H]([C@@H](O)[C@H](O)[C@@H]5O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)C(O)=O)C(O)=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
122272	BRD-K15318383	A375	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122338	BRD-K15318383	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122347	BRD-K15318383	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122427	BRD-K15318383	MDAMB231	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.78	0.09
122450	BRD-K15318383	PC3	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122497	BRD-K15318383	THP1	3.33 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12
130572	BRD-K15318383	A549	0.01 uM	24 h	0.0	0.0	0.0	-0.33	-1.1	0.87
130604	BRD-K15318383	HA1E	0.03 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.5
130641	BRD-K15318383	HEK293	0.25 uM	24 h	0.23	0.97	0.08	0.0	0.0	0.0
130750	BRD-K15318383	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130768	BRD-K15318383	MCF??7.00	2.22 uM	24 h	-0.25	-1.05	0.24	-0.39	-1.32	1.71
130848	BRD-K15318383	YAPC	0.08 uM	24 h	-0.19	-0.78	0.0	0.31	1.11	0.72

Summary