CMap Candidate Details
Structure:
| CMap ID: | C03011 |
| Pert ID: | BRD-A27376179 |
| Compound Name: | lestaurtinib |
| Targets: | FLT3|NTRK1 |
| MoA: | FLT3 inhibitor; growth factor receptor inhibitor; JAK inhibitor |
| SMILES: | C[C@]12OC(C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95456 | BRD-A27376179 | U2OS | 4 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.97 | 0.45 |
| 119980 | BRD-A27376179 | A549 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120020 | BRD-A27376179 | HA1E | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.25 | -0.84 | 0.18 |
| 120096 | BRD-A27376179 | HT29 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.28 | 1.0 | 0.42 |
| 120140 | BRD-A27376179 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128793 | BRD-A27376179 | A375 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.38 | 2.02 |
| 128826 | BRD-A27376179 | HELA | 0.25 uM | 24 h | 0.24 | 1.01 | 0.12 | -0.26 | -0.89 | 0.26 |
| 128845 | BRD-A27376179 | PC3 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128865 | BRD-A27376179 | YAPC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.95 | 0.41 |