CMap Candidate Details
Structure:
| CMap ID: | C03015 |
| Pert ID: | BRD-K88789588 |
| Compound Name: | letrozole |
| Targets: | CYP19A1 |
| MoA: | aromatase inhibitor |
| SMILES: | N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1cncn1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 7490 | BRD-K88789588 | HA1E | 10 uM | 6 h | 0.23 | 0.98 | 0.09 | 0.0 | 0.0 | 0.0 |
| 7725 | BRD-K88789588 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 24624 | BRD-K88789588 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 25268 | BRD-K88789588 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.21 | 0.74 | 0.04 |
| 25440 | BRD-K88789588 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 91119 | BRD-K88789588 | HUH7 | 12 uM | 72 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121726 | BRD-K88789588 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121827 | BRD-K88789588 | MCF??7.00 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.97 | 0.44 |
| 121878 | BRD-K88789588 | YAPC | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129853 | BRD-K88789588 | HEK293 | 0.25 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.81 | 0.14 |
| 129883 | BRD-K88789588 | HELA | 0.08 uM | 24 h | 0.25 | 1.04 | 0.15 | 0.0 | 0.0 | 0.0 |
| 129903 | BRD-K88789588 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.25 | -0.85 | 0.19 |
| 129978 | BRD-K88789588 | MCF10A | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.22 | 0.77 | 0.05 |
| 130064 | BRD-K88789588 | MDAMB231 | 0.03 uM | 24 h | 0.27 | 1.11 | 0.26 | 0.0 | 0.0 | 0.0 |
| 130135 | BRD-K88789588 | THP1 | 0.08 uM | 24 h | -0.27 | -1.11 | 0.37 | -0.19 | -0.64 | 0.01 |