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CMap Candidate Details

Structure:
CMap ID: C03042
Pert ID: BRD-K35189033
Compound Name: levonorgestrel
Targets: AR|ESR1|PGR|SRD5A1
MoA: estrogen receptor agonist; glucocorticoid receptor antagonist; progesterone receptor agonist; progesterone receptor antagonist
SMILES: CC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4421 BRD-K35189033 HCC515 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
25360 BRD-K35189033 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39677 BRD-K35189033 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39990 BRD-K35189033 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40797 BRD-K35189033 NEU 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.36
41099 BRD-K35189033 NPC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
41432 BRD-K35189033 SKB 10 uM 24 h -0.27 -1.12 0.39 0.0 0.0 0.0
91464 BRD-K35189033 HUH7 10 uM 72 h 0.0 0.0 0.0 0.25 0.9 0.22
95367 BRD-K35189033 MCF??7.00 1.11 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
99872 BRD-K35189033 U2OS 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126650 BRD-K35189033 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126671 BRD-K35189033 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126771 BRD-K35189033 JURKAT 10 uM 24 h -0.26 -1.08 0.31 0.0 0.0 0.0
126802 BRD-K35189033 MCF10A 10 uM 24 h -0.2 -0.84 0.01 -0.28 -0.95 0.41
126911 BRD-K35189033 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
126943 BRD-K35189033 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
126989 BRD-K35189033 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
134673 BRD-K35189033 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134762 BRD-K35189033 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.07
134794 BRD-K35189033 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134822 BRD-K35189033 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134858 BRD-K35189033 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134939 BRD-K35189033 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).