Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C03046
Pert ID: BRD-K30685142
Compound Name: levothyroxine
Targets: THRA|THRB
MoA: thyroid hormone stimulant
SMILES: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
51931 BRD-K30685142 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91493 BRD-K30685142 HUH7 4 uM 72 h 0.22 0.93 0.05 0.0 0.0 0.0
121896 BRD-K30685142 A375 10 uM 24 h -0.25 -1.06 0.26 0.27 0.96 0.34
122011 BRD-K30685142 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122052 BRD-K30685142 HUVEC 0.125 uM 24 h -0.25 -1.05 0.24 0.0 0.0 0.0
122108 BRD-K30685142 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122142 BRD-K30685142 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122195 BRD-K30685142 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130205 BRD-K30685142 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130231 BRD-K30685142 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130258 BRD-K30685142 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
130292 BRD-K30685142 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130353 BRD-K30685142 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130402 BRD-K30685142 MCF10A 0.74 uM 24 h -0.18 -0.77 0.0 0.23 0.8 0.08
130524 BRD-K30685142 YAPC 2.22 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).