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CMap Candidate Details

Structure:
CMap ID: C03049
Pert ID: BRD-A56085258
Compound Name: LGX818
Targets: BRAF
MoA: RAF inhibitor
SMILES: COC(=O)NC(C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90644 BRD-A56085258 HCT116 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98090 BRD-A56085258 P1A82 3.33 uM 24 h 0.27 1.11 0.25 -0.3 -1.01 0.58
123553 BRD-A56085258 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
123608 BRD-A56085258 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123635 BRD-A56085258 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.22 0.8 0.08
123673 BRD-A56085258 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
123720 BRD-A56085258 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123738 BRD-A56085258 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123756 BRD-A56085258 YAPC 10 uM 24 h 0.22 0.9 0.03 0.42 1.5 2.27
131967 BRD-A56085258 A375 0.03 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
132003 BRD-A56085258 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).