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CMap Candidate Details

Structure:
CMap ID: C03056
Pert ID: BRD-K52662033
Compound Name: lidocaine
Targets: EGFR|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A
MoA: histamine receptor agonist
SMILES: CCN(CC)CC(=O)Nc1c(C)cccc1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4578 BRD-K52662033 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4937 BRD-K52662033 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24680 BRD-K52662033 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37689 BRD-K52662033 ASC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
37919 BRD-K52662033 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38512 BRD-K52662033 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
38744 BRD-K52662033 PHH 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
38972 BRD-K52662033 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90985 BRD-K52662033 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99639 BRD-K52662033 U2OS 20 uM 6 h 0.28 1.19 0.41 0.23 0.8 0.08
124411 BRD-K52662033 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
124513 BRD-K52662033 PC3 1.11 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
124542 BRD-K52662033 YAPC 0.04 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
132326 BRD-K52662033 A375 0.74 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
132384 BRD-K52662033 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132419 BRD-K52662033 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.4 -1.33 1.77
132441 BRD-K52662033 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132460 BRD-K52662033 HT29 0.74 uM 24 h -0.27 -1.14 0.42 -0.35 -1.17 1.11
132488 BRD-K52662033 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
132518 BRD-K52662033 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
132549 BRD-K52662033 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132598 BRD-K52662033 THP1 0.25 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).