CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C03057
Pert ID:	BRD-K62996583
Compound Name:	lidoflazine
Targets:	SCN1A\|SCN3A\|SLC29A1
MoA:	calcium channel blocker
SMILES:	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4128	BRD-K62996583	HA1E	10 uM	24 h	-0.26	-1.07	0.27	-0.28	-0.95	0.4
4452	BRD-K62996583	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5100	BRD-K62996583	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39728	BRD-K62996583	ASC	10 uM	24 h	0.0	0.0	0.0	0.25	0.88	0.18
40025	BRD-K62996583	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.22	-0.75	0.06
40839	BRD-K62996583	NEU	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.93	0.34
41146	BRD-K62996583	NPC	10 uM	24 h	-0.29	-1.19	0.55	-0.43	-1.45	15.35
41484	BRD-K62996583	SKB	10 uM	24 h	-0.26	-1.07	0.28	-0.29	-0.97	0.46
99314	BRD-K62996583	U2OS	4 uM	6 h	0.0	0.0	0.0	0.32	1.15	0.88
124577	BRD-K62996583	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124595	BRD-K62996583	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124658	BRD-K62996583	HELA	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.11
124691	BRD-K62996583	HT29	10 uM	24 h	0.0	0.0	0.0	0.2	0.71	0.02
124722	BRD-K62996583	JURKAT	0.37 uM	24 h	-0.21	-0.86	0.01	0.26	0.93	0.27
124794	BRD-K62996583	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124835	BRD-K62996583	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124877	BRD-K62996583	THP1	10 uM	24 h	-0.23	-0.95	0.09	-0.3	-1.0	0.55
124914	BRD-K62996583	YAPC	10 uM	24 h	0.2	0.85	0.0	0.45	1.59	2.37
132751	BRD-K62996583	HEK293	0.25 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.28
132866	BRD-K62996583	MCF10A	0.01 uM	24 h	-0.22	-0.92	0.06	-0.43	-1.45	15.35
132897	BRD-K62996583	MCF??7.00	0.25 uM	24 h	-0.2	-0.83	0.0	-0.25	-0.85	0.2

Summary