CMap Candidate Details
Structure:
| CMap ID: | C00306 |
| Pert ID: | BRD-K56334280 |
| Compound Name: | amonafide |
| Targets: | TOP2A|TOP2B |
| MoA: | topoisomerase inhibitor |
| SMILES: | CN(C)CCN1C(=O)c2cccc3cc(N)cc(C1=O)c23 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 29889 | BRD-K56334280 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 30218 | BRD-K56334280 | A549 | 10 uM | 6 h | 0.2 | 0.84 | 0.0 | 0.26 | 0.92 | 0.25 |
| 30785 | BRD-K56334280 | HA1E | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.13 | 0.97 |
| 31079 | BRD-K56334280 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 31386 | BRD-K56334280 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.0 | 0.52 |
| 31507 | BRD-K56334280 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.08 | 0.8 |
| 32046 | BRD-K56334280 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 33065 | BRD-K56334280 | SKB | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 33313 | BRD-K56334280 | VCAP | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 123888 | BRD-K56334280 | HEK293 | 3.33 uM | 24 h | 0.28 | 1.17 | 0.38 | -0.39 | -1.32 | 1.71 |
| 123938 | BRD-K56334280 | HELA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.98 | 0.5 |
| 123987 | BRD-K56334280 | JURKAT | 3.33 uM | 24 h | -0.22 | -0.93 | 0.07 | -0.33 | -1.11 | 0.91 |
| 124043 | BRD-K56334280 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.87 | 0.24 |
| 124150 | BRD-K56334280 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.32 | -1.06 | 0.75 |
| 124170 | BRD-K56334280 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 124223 | BRD-K56334280 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 132271 | BRD-K56334280 | MDAMB231 | 2.22 uM | 24 h | 0.26 | 1.08 | 0.21 | 0.0 | 0.0 | 0.0 |