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CMap Candidate Details

Structure:
CMap ID: C03067
Pert ID: BRD-K66876909
Compound Name: linezolid
Targets: MAOA|MAOB
MoA: bacterial 50S ribosomal subunit inhibitor
SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(F)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25180 BRD-K66876909 PC3 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
25408 BRD-K66876909 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30521 BRD-K66876909 ASC 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.43
31106 BRD-K66876909 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31417 BRD-K66876909 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32497 BRD-K66876909 NPC 10 uM 24 h 0.31 1.29 0.64 0.2 0.69 0.01
33104 BRD-K66876909 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91086 BRD-K66876909 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
124946 BRD-K66876909 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124981 BRD-K66876909 A549 10 uM 24 h -0.2 -0.85 0.01 -0.38 -1.29 1.53
125041 BRD-K66876909 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125083 BRD-K66876909 MCF10A 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
125181 BRD-K66876909 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133021 BRD-K66876909 HA1E 0.74 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
133071 BRD-K66876909 HEK293 2.22 uM 24 h -0.19 -0.78 0.0 -0.33 -1.11 0.9
133129 BRD-K66876909 HT29 0.03 uM 24 h 0.33 1.36 0.97 0.0 0.0 0.0
133178 BRD-K66876909 JURKAT 0.03 uM 24 h -0.24 -1.01 0.17 -0.24 -0.82 0.15
133241 BRD-K66876909 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133270 BRD-K66876909 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133324 BRD-K66876909 YAPC 2.22 uM 24 h -0.2 -0.85 0.01 -0.3 -1.0 0.52
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).