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CMap Candidate Details

Structure:
CMap ID: C03068
Pert ID: BRD-K99749624
Compound Name: linifanib
Targets: CSF1|CSF1R|FLT1|FLT3|FLT4|KDR|KIT|PDGFRB|RET|TEK
MoA: PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES: Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
510 BRD-K99749624 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
544 BRD-K99749624 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
606 BRD-K99749624 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
647 BRD-K99749624 KMS34 10 uM 24 h -0.25 -1.05 0.23 -0.26 -0.86 0.22
693 BRD-K99749624 MINO 10 uM 24 h -0.23 -0.98 0.12 -0.23 -0.78 0.09
741 BRD-K99749624 NALM6 10 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
794 BRD-K99749624 OCILY19 2.5 uM 4 h 0.0 0.0 0.0 -0.24 -0.8 0.12
816 BRD-K99749624 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.49
883 BRD-K99749624 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
924 BRD-K99749624 THP1 10 uM 24 h -0.28 -1.19 0.51 0.27 0.96 0.34
973 BRD-K99749624 TMD8 2.5 uM 4 h 0.2 0.85 0.01 0.0 0.0 0.0
34226 BRD-K99749624 ASC 10 uM 24 h -0.27 -1.14 0.43 -0.32 -1.08 0.79
34729 BRD-K99749624 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35880 BRD-K99749624 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.94
36697 BRD-K99749624 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37021 BRD-K99749624 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
91869 BRD-K99749624 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91976 BRD-K99749624 SKBR3 10 uM 6 h -0.22 -0.91 0.05 0.23 0.8 0.08
92439 BRD-K99749624 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92472 BRD-K99749624 BT20 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92560 BRD-K99749624 HME1 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92609 BRD-K99749624 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92675 BRD-K99749624 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92739 BRD-K99749624 MCF10A 0.04 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92775 BRD-K99749624 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95651 BRD-K99749624 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95985 BRD-K99749624 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118225 BRD-K99749624 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127755 BRD-K99749624 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127883 BRD-K99749624 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127957 BRD-K99749624 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
128057 BRD-K99749624 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128090 BRD-K99749624 YAPC 10 uM 24 h -0.22 -0.9 0.04 0.26 0.91 0.24
135531 BRD-K99749624 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135584 BRD-K99749624 HELA 2.22 uM 24 h 0.34 1.4 1.02 0.0 0.0 0.0
135624 BRD-K99749624 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135675 BRD-K99749624 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).